Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data

Allelic expression imbalance (AEI), quantified by the relative expression of two alleles of a gene in a diploid organism, can help explain phenotypic variations among individuals. Traditional methods detect AEI using bulk RNA sequencing (RNA-seq) data, a data type that averages out cell-to-cell hete...

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Detalles Bibliográficos
Autores principales: Fan, Jiaxin, Wang, Xuran, Xiao, Rui, Li, Mingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963069/
https://www.ncbi.nlm.nih.gov/pubmed/33661921
http://dx.doi.org/10.1371/journal.pgen.1009080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963069/
https://www.ncbi.nlm.nih.gov/pubmed/33661921
http://dx.doi.org/10.1371/journal.pgen.1009080

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