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Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data
Allelic expression imbalance (AEI), quantified by the relative expression of two alleles of a gene in a diploid organism, can help explain phenotypic variations among individuals. Traditional methods detect AEI using bulk RNA sequencing (RNA-seq) data, a data type that averages out cell-to-cell hete...
Autores principales: | Fan, Jiaxin, Wang, Xuran, Xiao, Rui, Li, Mingyao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963069/ https://www.ncbi.nlm.nih.gov/pubmed/33661921 http://dx.doi.org/10.1371/journal.pgen.1009080 |
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