PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity

PD-1 is expressed on exhausted T cells in cancer patients but its physiological role remains uncertain. We determined the phenotype, function and transcriptional correlates of PD-1 expression on cytomegalovirus-specific CD4+ T cells during latent infection. PD-1 expression ranged from 10–85% and rem...

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Detalles Bibliográficos
Autores principales: Parry, Helen M., Dowell, Alexander C., Zuo, Jianmin, Verma, Kriti, Kinsella, Francesca A. M., Begum, Jusnara, Croft, Wayne, Sharma-Oates, Archana, Pratt, Guy, Moss, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963093/
https://www.ncbi.nlm.nih.gov/pubmed/33662046
http://dx.doi.org/10.1371/journal.ppat.1009349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963093/
https://www.ncbi.nlm.nih.gov/pubmed/33662046
http://dx.doi.org/10.1371/journal.ppat.1009349

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