Age‐associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon

One of the hallmarks of aging is an accumulation of cells with defects in oxidative phosphorylation (OXPHOS) due to mutations of mitochondrial DNA (mtDNA). Rapidly dividing tissues maintained by stem cells, such as the colonic epithelium, are particularly susceptible to accumulation of OXPHOS defect...

Descripción completa

Detalles Bibliográficos
Autores principales: Stamp, Craig, Whitehall, Julia C., Smith, Anna L. M., Houghton, David, Bradshaw, Carla, Stoll, Elizabeth A., Blain, Alasdair P., Turnbull, Doug M., Greaves, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963326/
https://www.ncbi.nlm.nih.gov/pubmed/33626245
http://dx.doi.org/10.1111/acel.13321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963326/
https://www.ncbi.nlm.nih.gov/pubmed/33626245
http://dx.doi.org/10.1111/acel.13321

Ejemplares similares