Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionoph...

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Detalles Bibliográficos
Autores principales: Carrasquel-Ursulaez, Willy, Reeves, Ryan D., Dehghany, Mahzad, Jones, Corey, Schomaker, Jennifer M., Chanda, Baron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963367/
https://www.ncbi.nlm.nih.gov/pubmed/33732448
http://dx.doi.org/10.1039/d0ra08494h
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author Carrasquel-Ursulaez, Willy
Reeves, Ryan D.
Dehghany, Mahzad
Jones, Corey
Schomaker, Jennifer M.
Chanda, Baron
author_facet Carrasquel-Ursulaez, Willy
Reeves, Ryan D.
Dehghany, Mahzad
Jones, Corey
Schomaker, Jennifer M.
Chanda, Baron
author_sort Carrasquel-Ursulaez, Willy
collection PubMed
description The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.
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spelling pubmed-79633672021-03-16 Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds Carrasquel-Ursulaez, Willy Reeves, Ryan D. Dehghany, Mahzad Jones, Corey Schomaker, Jennifer M. Chanda, Baron RSC Adv Chemistry The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores. The Royal Society of Chemistry 2020-11-05 /pmc/articles/PMC7963367/ /pubmed/33732448 http://dx.doi.org/10.1039/d0ra08494h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Carrasquel-Ursulaez, Willy
Reeves, Ryan D.
Dehghany, Mahzad
Jones, Corey
Schomaker, Jennifer M.
Chanda, Baron
Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title_full Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title_fullStr Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title_full_unstemmed Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title_short Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
title_sort re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963367/
https://www.ncbi.nlm.nih.gov/pubmed/33732448
http://dx.doi.org/10.1039/d0ra08494h
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