FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

OBJECTIVE: Forkhead box protein O1 (FOXO1) plays a key role in regulating hepatic glucose production, but investigations of FOXO1 inhibition as a potential therapeutic approach have been hampered by a lack of selective chemical inhibitors. By profiling structurally diverse FOXO1 inhibitors, the curr...

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Detalles Bibliográficos
Autores principales: Lee, Yun-Kyoung, Diaz, Bryan, Deroose, Marianne, Lee, Samuel X., Belvedere, Sandro, Accili, Domenico, Leibel, Rudolph L., Lin, Hua V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966865/
https://www.ncbi.nlm.nih.gov/pubmed/33577983
http://dx.doi.org/10.1016/j.molmet.2021.101187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966865/
https://www.ncbi.nlm.nih.gov/pubmed/33577983
http://dx.doi.org/10.1016/j.molmet.2021.101187

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