Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth

Many patients fail to respond to EGFR-targeted therapeutics, and personalized diagnostics is needed to identify putative responders. We investigated 1630 colorectal and lung squamous carcinomas and 1357 normal lung and colon samples and observed huge variation in EGFR pathway activation in both canc...

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Detalles Bibliográficos
Autores principales: Kamashev, Dmitry, Sorokin, Maksim, Kochergina, Irina, Drobyshev, Aleksey, Vladimirova, Uliana, Zolotovskaia, Marianna, Vorotnikov, Igor, Shaban, Nina, Raevskiy, Mikhail, Kuzmin, Denis, Buzdin, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966997/
https://www.ncbi.nlm.nih.gov/pubmed/33748471
http://dx.doi.org/10.1016/j.heliyon.2021.e06394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966997/
https://www.ncbi.nlm.nih.gov/pubmed/33748471
http://dx.doi.org/10.1016/j.heliyon.2021.e06394

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