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Lacto-N-biose synthesis via a modular enzymatic cascade with ATP regeneration

Human milk oligosaccharides (HMOs), the third most abundant solid component of human milk, are reported to be beneficial to infant health. The biosynthesis of lacto-N-biose (LNB), the building block for HMOs, suffers from excessive addition of cofactors and intermediate inhibition. Here, we develope...

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Detalles Bibliográficos
Autores principales: Du, Zhiqiang, Liu, Zhengyao, Tan, Yinshuang, Niu, Kangle, Guo, Wei, Jia, Yangyang, Fang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967015/
https://www.ncbi.nlm.nih.gov/pubmed/33748718
http://dx.doi.org/10.1016/j.isci.2021.102236