Cargando…

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice

Alzheimer’s disease (AD) is the most common form of dementia. In particular, neuroinflammation, mediated by microglia cells but also through CD8+ T-cells, actively contributes to disease pathology. Leukotrienes are involved in neuroinflammation and in the pathological hallmarks of AD. In consequence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michael, Johanna, Zirknitzer, Julia, Unger, Michael Stefan, Poupardin, Rodolphe, Rieß, Tanja, Paiement, Nadine, Zerbe, Horst, Hutter-Paier, Birgit, Reitsamer, Herbert, Aigner, Ludwig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967180/ https://www.ncbi.nlm.nih.gov/pubmed/33803482 http://dx.doi.org/10.3390/ijms22052782

Ejemplares similares

The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic
por: Aigner, Ludwig, et al.
Publicado: (2020)

Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice
por: Michael, Johanna, et al.
Publicado: (2020)

Leukotriene Signaling as a Target in α-Synucleinopathies
por: Strempfl, Katharina, et al.
Publicado: (2022)

The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
por: Marschallinger, Julia, et al.
Publicado: (2020)

Potential Effects of Leukotriene Receptor Antagonist Montelukast in Treatment of Neuroinflammation in Parkinson’s Disease
por: Wallin, Johan, et al.
Publicado: (2021)

Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist?
por: Tintinger, Gregory R., et al.
Publicado: (2010)

Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist
por: Kemp, James P
Publicado: (2009)

Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
por: Michael, J., et al.
Publicado: (2020)

Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
por: Rodríguez-Urgellés, Ened, et al.
Publicado: (2022)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats
por: Otunctemur, Alper, et al.
Publicado: (2015)

Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
por: Marques, Cátia F., et al.
Publicado: (2022)

170 Combination of a Nasal Antihistamine Olopatadine and A Leukotriene Receptor Antagonist Montelukast Sodium for the Treatment of Seasonal Allergic Patients not Currently Controlled on Monotherapy Intranasal Antihistamine or a Leukotriene Receptor Antagonist
por: Nsouli, Safa
Publicado: (2012)

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice
por: Ou-Yang, Ming-Hsuan, et al.
Publicado: (2013)

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative
por: Ullah, Rahim, et al.
Publicado: (2020)

Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2020)

Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Dafnis, Ioannis, et al.
Publicado: (2022)

Effects of oral cysteine leukotriene receptor antagonist-montelukast on adenoid lymphoid tissue: a histopathological study under light microscope
por: Wang, Zhengying, et al.
Publicado: (2023)

Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells
por: Koller, Andreas, et al.
Publicado: (2020)

Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
por: Prange-Kiel, Janine, et al.
Publicado: (2016)

Leukotriene Antagonists in Dermatology
por: Bubna, Aditya Kumar
Publicado: (2021)

Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation
por: Kawai, Yohei, et al.
Publicado: (2019)

Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2
por: Jeon, Seung Ho, et al.
Publicado: (2020)

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
por: Wang, Lu, et al.
Publicado: (2016)

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
por: Chu, Tak-Ho, et al.
Publicado: (2017)

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice
por: Jeon, Seong Gak, et al.
Publicado: (2020)

Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer’s disease
por: Lim, Jeremiah K. H., et al.
Publicado: (2021)

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
por: Forner, Stefania, et al.
Publicado: (2021)

Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer’s Disease Mouse Model
por: Jeong, Ye Ji, et al.
Publicado: (2021)

Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity
por: Al-kuraishy, Hayder M., et al.
Publicado: (2021)

Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis
por: Cheng, Xiao, et al.
Publicado: (2023)

Alleviation of Cognitive Impairment-like Behaviors, Neuroinflammation, Colitis, and Gut Dysbiosis in 5xFAD Transgenic and Aged Mice by Lactobacillus mucosae and Bifidobacterium longum
por: Ma, Xiaoyang, et al.
Publicado: (2023)

The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-K(ATP) channels pathway
por: Ghorbanzadeh, Behnam, et al.
Publicado: (2022)

Leukotriene Receptor Antagonist, Montelukast Ameliorates L-NAME-Induced Pre-eclampsia in Rats through Suppressing the IL-6/Jak2/STAT3 Signaling Pathway
por: Abdelzaher, Walaa Yehia, et al.
Publicado: (2022)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Lim, Jeremiah K. H., et al.
Publicado: (2020)

Upregulation of Vitamin C Transporter Functional Expression in 5xFAD Mouse Intestine
por: Teafatiller, Trevor, et al.
Publicado: (2021)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022)

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease
por: Jullienne, Amandine, et al.
Publicado: (2023)

Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice
por: Samuel, Itia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_huuvi9ruqqmlpagh1u5oso6891