Cargando…

Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents

We synthesized a series of novel 3-carboranyl-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, using click chemistry, reductive amination and amidation reactions and investigated their in vitro effects on cytotoxicity, cell death, cell cycle, and the production of reactive oxygen spec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rykowski, Sebastian, Gurda-Woźna, Dorota, Orlicka-Płocka, Marta, Fedoruk-Wyszomirska, Agnieszka, Giel-Pietraszuk, Małgorzata, Wyszko, Eliza, Kowalczyk, Aleksandra, Stączek, Paweł, Bak, Andrzej, Kiliszek, Agnieszka, Rypniewski, Wojciech, Olejniczak, Agnieszka B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967199/ https://www.ncbi.nlm.nih.gov/pubmed/33803403 http://dx.doi.org/10.3390/ijms22052772

Ejemplares similares

Design of DNA Intercalators Based on 4-Carboranyl-1,8-Naphthalimides: Investigation of Their DNA-Binding Ability and Anticancer Activity
por: Rykowski, Sebastian, et al.
Publicado: (2022)

Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines
por: Rykowski, Sebastian, et al.
Publicado: (2023)

Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside
por: Orlicka-Płocka, Marta, et al.
Publicado: (2020)

Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives
por: Orlicka-Płocka, Marta, et al.
Publicado: (2021)

Novel Isoniazid-Carborane Hybrids Active In Vitro against Mycobacterium tuberculosis
por: Różycka, Daria, et al.
Publicado: (2020)

Antiaging Effect of 4-N-Furfurylcytosine in Yeast Model Manifests through Enhancement of Mitochondrial Activity and ROS Reduction
por: Pawelczak, Paweł, et al.
Publicado: (2022)

β-Carbolines in Experiments on Laboratory Animals
por: Zawirska-Wojtasiak, Renata, et al.
Publicado: (2020)

Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli
por: Korycka-Machala, Malgorzata, et al.
Publicado: (2017)

Structural studies of CNG repeats
por: Kiliszek, Agnieszka, et al.
Publicado: (2014)

Preparation of dendritic carboranyl glycoconjugates as potential anticancer therapeutics
por: Swain, Biswa Ranjan, et al.
Publicado: (2020)

The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs
por: Kiliszek, Agnieszka, et al.
Publicado: (2016)

Watson–Crick-like pairs in CCUG repeats: evidence for tautomeric shifts or protonation
por: Rypniewski, Wojciech, et al.
Publicado: (2016)

Stabilization of RNA hairpins using non-nucleotide linkers and circularization
por: Kiliszek, Agnieszka, et al.
Publicado: (2017)

Broken symmetry between RNA enantiomers in a crystal lattice
por: Kiliszek, Agnieszka, et al.
Publicado: (2021)

Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome
por: Kiliszek, Agnieszka, et al.
Publicado: (2011)

Structural insights into CUG repeats containing the ‘stretched U–U wobble’: implications for myotonic dystrophy
por: Kiliszek, Agnieszka, et al.
Publicado: (2009)

Crystallographic characterization of CCG repeats
por: Kiliszek, Agnieszka, et al.
Publicado: (2012)

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases
por: Kiliszek, Agnieszka, et al.
Publicado: (2010)

Cholesterol-Bearing Fluorescent G-Quadruplex Potassium Probes for Anchoring at the Langmuir Monolayer and Cell Membrane
por: Świtalska, Angelika, et al.
Publicado: (2018)

Development of fluorescence oligonucleotide probes based on cytosine- and guanine-rich sequences
por: Dembska, Anna, et al.
Publicado: (2020)

Inhibition of miR-21 in glioma cells using catalytic nucleic acids
por: Belter, Agnieszka, et al.
Publicado: (2016)

Fluorinated Analogues of Lepidilines A and C: Synthesis and Screening of Their Anticancer and Antiviral Activity
por: Mlostoń, Grzegorz, et al.
Publicado: (2022)

Modular Synthetic Approach to Carboranyl‒Biomolecules Conjugates
por: Kellert, Martin, et al.
Publicado: (2021)

Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation
por: Useini, Liridona, et al.
Publicado: (2022)

Translation of human Δ133p53 mRNA and its targeting by antisense oligonucleotides complementary to the 5′-terminal region of this mRNA
por: Żydowicz-Machtel, Paulina, et al.
Publicado: (2021)

Cross-reactivity between histone demethylase inhibitor valproic acid and DNA methylation in glioblastoma cell lines
por: Barciszewska, Anna-Maria, et al.
Publicado: (2022)

Juglone in Combination with Temozolomide Shows a Promising Epigenetic Therapeutic Effect on the Glioblastoma Cell Line
por: Barciszewska, Anna-Maria, et al.
Publicado: (2023)

Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment
por: Wawrzyniak, Dariusz, et al.
Publicado: (2020)

Design, Synthesis and Evaluation of Naphthalimide Derivatives as Potential Anticancer Agents for Hepatocellular Carcinoma
por: Ge, Chaochao, et al.
Publicado: (2017)

Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats
por: Mukherjee, Sanjukta, et al.
Publicado: (2019)

Synthesis and (11)C-Radiolabelling of 2-Carboranyl Benzothiazoles
por: Gona, Kiran B., et al.
Publicado: (2015)

The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality
por: Wyszko, Eliza, et al.
Publicado: (2021)

New Acceptor–Donor–Acceptor Systems Based on Bis-(Imino-1,8-Naphthalimide)
por: Kotowicz, Sonia, et al.
Publicado: (2021)

Carboranyl-Chlorin e(6) as a Potent Antimicrobial Photosensitizer
por: Omarova, Elena O., et al.
Publicado: (2015)

Synthesis and Structure of Nido-Carboranyl Azide and Its “Click” Reactions
por: Druzina, Anna A., et al.
Publicado: (2021)

Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers
por: Huang, Yu, et al.
Publicado: (2018)

Alkene insertion reactivity of a o-carboranyl-substituted 9-borafluorene
por: Bischof, Tobias, et al.
Publicado: (2022)

Tris(ortho‐carboranyl)borane: An Isolable, Halogen‐Free, Lewis Superacid
por: Akram, Manjur O., et al.
Publicado: (2022)

Hydrostatic and osmotic pressure study of the RNA hydration
por: Giel-Pietraszuk, Małgorzata, et al.
Publicado: (2012)

Cytotoxic effects of halophilic archaea metabolites on ovarian cancer cell lines
por: Kowalewicz-Kulbat, Magdalena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nbcjmgetk52j92dvf4li53aob2