Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca(2+) alteration and multiphasic transmitter release

Excessive amounts of amyloid β (Aβ) peptide have been suggested to dysregulate synaptic transmission in Alzheimer’s disease (AD). As a major type of glial cell in the mammalian brain, astrocytes regulate neuronal function and undergo activity alterations upon Aβ exposure. Yet the mechanistic steps u...

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Detalles Bibliográficos
Autores principales: Pham, Cuong, Hérault, Karine, Oheim, Martin, Maldera, Steeve, Vialou, Vincent, Cauli, Bruno, Li, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968286/
https://www.ncbi.nlm.nih.gov/pubmed/33726852
http://dx.doi.org/10.1186/s40478-021-01146-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968286/
https://www.ncbi.nlm.nih.gov/pubmed/33726852
http://dx.doi.org/10.1186/s40478-021-01146-1

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