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Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca(2+) alteration and multiphasic transmitter release
Excessive amounts of amyloid β (Aβ) peptide have been suggested to dysregulate synaptic transmission in Alzheimer’s disease (AD). As a major type of glial cell in the mammalian brain, astrocytes regulate neuronal function and undergo activity alterations upon Aβ exposure. Yet the mechanistic steps u...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968286/ https://www.ncbi.nlm.nih.gov/pubmed/33726852 http://dx.doi.org/10.1186/s40478-021-01146-1 |