Omnitemporal choreographies of all five STIM/Orai and IP(3)Rs underlie the complexity of mammalian Ca(2+) signaling

Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca(2+) depletion and activate Orai channels. However, the choreography of interactions between native STIM/Orai proteins under physiological agonist stimulation is unknown. We show that the five STIM1/2 and Orai1/2/3 proteins a...

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Detalles Bibliográficos
Autores principales: Emrich, Scott M., Yoast, Ryan E., Xin, Ping, Arige, Vikas, Wagner, Larry E., Hempel, Nadine, Gill, Donald L., Sneyd, James, Yule, David I., Trebak, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968378/
https://www.ncbi.nlm.nih.gov/pubmed/33657364
http://dx.doi.org/10.1016/j.celrep.2021.108760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968378/
https://www.ncbi.nlm.nih.gov/pubmed/33657364
http://dx.doi.org/10.1016/j.celrep.2021.108760

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