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Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae
Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent segregation of homologous chromosomes during meiosis. Although DSBs are induced to high levels in meiosis, their formation and repair are tig...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968521/ https://www.ncbi.nlm.nih.gov/pubmed/33748134 http://dx.doi.org/10.3389/fcell.2021.642737 |
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author | Yadav, Vikash Kumar Claeys Bouuaert, Corentin |
author_facet | Yadav, Vikash Kumar Claeys Bouuaert, Corentin |
author_sort | Yadav, Vikash Kumar |
collection | PubMed |
description | Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent segregation of homologous chromosomes during meiosis. Although DSBs are induced to high levels in meiosis, their formation and repair are tightly regulated to minimize potentially dangerous consequences for genomic integrity. In S. cerevisiae, nine proteins participate with Spo11 in DSB formation, but their molecular functions have been challenging to define. Here, we describe our current view of the mechanism of meiotic DSB formation based on recent advances in the characterization of the structure and function of DSB proteins and discuss regulatory pathways in the light of recent models. |
format | Online Article Text |
id | pubmed-7968521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79685212021-03-18 Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae Yadav, Vikash Kumar Claeys Bouuaert, Corentin Front Cell Dev Biol Cell and Developmental Biology Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent segregation of homologous chromosomes during meiosis. Although DSBs are induced to high levels in meiosis, their formation and repair are tightly regulated to minimize potentially dangerous consequences for genomic integrity. In S. cerevisiae, nine proteins participate with Spo11 in DSB formation, but their molecular functions have been challenging to define. Here, we describe our current view of the mechanism of meiotic DSB formation based on recent advances in the characterization of the structure and function of DSB proteins and discuss regulatory pathways in the light of recent models. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC7968521/ /pubmed/33748134 http://dx.doi.org/10.3389/fcell.2021.642737 Text en Copyright © 2021 Yadav and Claeys Bouuaert. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Yadav, Vikash Kumar Claeys Bouuaert, Corentin Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title | Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title_full | Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title_fullStr | Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title_full_unstemmed | Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title_short | Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae |
title_sort | mechanism and control of meiotic dna double-strand break formation in s. cerevisiae |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968521/ https://www.ncbi.nlm.nih.gov/pubmed/33748134 http://dx.doi.org/10.3389/fcell.2021.642737 |
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