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Extracellular matrix density regulates the formation of tumour spheroids through cell migration

In this work, we show how the mechanical properties of the cellular microenvironment modulate the growth of tumour spheroids. Based on the composition of the extracellular matrix, its stiffness and architecture can significantly vary, subsequently influencing cell movement and tumour growth. However...

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Detalles Bibliográficos
Autores principales: Gonçalves, Inês G., Garcia-Aznar, Jose Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968691/
https://www.ncbi.nlm.nih.gov/pubmed/33635856
http://dx.doi.org/10.1371/journal.pcbi.1008764