GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residues T553/S554, which stabilizes ERα protein by inhibiting asso...

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Detalles Bibliográficos
Autores principales: Shin, Eun Myoung, Huynh, Vinh Thang, Neja, Sultan Abda, Liu, Chia Yi, Raju, Anandhkumar, Tan, Kelly, Tan, Nguan Soon, Gunaratne, Jayantha, Bi, Xuezhi, Iyer, Lakshminarayan M., Aravind, L., Tergaonkar, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968844/
https://www.ncbi.nlm.nih.gov/pubmed/33731348
http://dx.doi.org/10.1126/sciadv.abe2470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968844/
https://www.ncbi.nlm.nih.gov/pubmed/33731348
http://dx.doi.org/10.1126/sciadv.abe2470

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