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Breast cancer–secreted factors perturb murine bone growth in regions prone to metastasis

Breast cancer frequently metastasizes to bone, causing osteolytic lesions. However, how factors secreted by primary tumors affect the bone microenvironment before the osteolytic phase of metastatic tumor growth remains unclear. Understanding these changes is critical as they may regulate metastatic...

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Detalles Bibliográficos
Autores principales: Chiou, Aaron E., Liu, Chuang, Moreno-Jiménez, Inés, Tang, Tengteng, Wagermaier, Wolfgang, Dean, Mason N., Fischbach, Claudia, Fratzl, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968847/
https://www.ncbi.nlm.nih.gov/pubmed/33731354
http://dx.doi.org/10.1126/sciadv.abf2283