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Adaptive immunity to human coronaviruses is widespread but low in magnitude

OBJECTIVES: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV‐specific T‐cell memory in adults. METHODS: We quantified CD4 T‐cell and antibody responses to hCoV spike an...

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Detalles Bibliográficos
Autores principales: Tan, Hyon‐Xhi, Lee, Wen Shi, Wragg, Kathleen M, Nelson, Christina, Esterbauer, Robyn, Kelly, Hannah G, Amarasena, Thakshila, Jones, Robert, Starkey, Graham, Wang, Bao Zhong, Yoshino, Osamu, Tiang, Thomas, Grayson, Michael Lindsay, Opdam, Helen, D'Costa, Rohit, Vago, Angela, Mackay, Laura K, Gordon, Claire L, Wheatley, Adam K, Kent, Stephen J, Juno, Jennifer A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968850/
https://www.ncbi.nlm.nih.gov/pubmed/33747512
http://dx.doi.org/10.1002/cti2.1264