N (6)-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors

We used quench flow to study how N(6)-methylated adenosines (m(6)A) affect the accuracy ratio between k(cat)/K(m) (i.e. association rate constant (k(a)) times probability (P(p)) of product formation after enzyme-substrate complex formation) for cognate and near-cognate substrate for mRNA reading by...

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Detalles Bibliográficos
Autores principales: Ieong, Ka-Weng, Indrisiunaite, Gabriele, Prabhakar, Arjun, Puglisi, Joseph D, Ehrenberg, Måns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969026/
https://www.ncbi.nlm.nih.gov/pubmed/33561188
http://dx.doi.org/10.1093/nar/gkab033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969026/
https://www.ncbi.nlm.nih.gov/pubmed/33561188
http://dx.doi.org/10.1093/nar/gkab033

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