SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining

Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these...

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Detalles Bibliográficos
Autores principales: Akimova, Ekaterina, Gassner, Franz Josef, Schubert, Maria, Rebhandl, Stefan, Arzt, Claudia, Rauscher, Stefanie, Tober, Vanessa, Zaborsky, Nadja, Greil, Richard, Geisberger, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969033/
https://www.ncbi.nlm.nih.gov/pubmed/33591315
http://dx.doi.org/10.1093/nar/gkab051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969033/
https://www.ncbi.nlm.nih.gov/pubmed/33591315
http://dx.doi.org/10.1093/nar/gkab051

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