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SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining
Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969033/ https://www.ncbi.nlm.nih.gov/pubmed/33591315 http://dx.doi.org/10.1093/nar/gkab051 |