Structural mechanism of DNA recognition by the p204 HIN domain

The interferon gamma-inducible protein 16 (IFI16) and its murine homologous protein p204 function in non-sequence specific dsDNA sensing; however, the exact dsDNA recognition mechanisms of IFI16/p204, which harbour two HIN domains, remain unclear. In the present study, we determined crystal structur...

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Detalles Bibliográficos
Autores principales: Fan, Xiaojiao, Jiang, Jiansheng, Zhao, Dan, Chen, Feng, Ma, Huan, Smith, Patrick, Unterholzner, Leonie, Xiao, Tsan Sam, Jin, Tengchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969034/
https://www.ncbi.nlm.nih.gov/pubmed/33619523
http://dx.doi.org/10.1093/nar/gkab076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969034/
https://www.ncbi.nlm.nih.gov/pubmed/33619523
http://dx.doi.org/10.1093/nar/gkab076

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