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Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy
Spontaneous intracerebral hemorrhage (ICH) commonly causes secondary hippocampal damage and delayed cognitive impairments, but the mechanisms remain elusive. Here, we sought to identify the molecular mechanisms underlying these hemorrhagic outcomes in a rat autologous blood model of ICH. First, a si...
Autores principales: | Zhao, Manman, Gao, Junling, Cui, Changmeng, Zhang, Yanan, Jiang, Xiaohua, Cui, Jianzhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969103/ https://www.ncbi.nlm.nih.gov/pubmed/33777313 http://dx.doi.org/10.1155/2021/5472605 |
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