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Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071

RATIONALE: In addition to the disease-defining motor symptoms, patients with Parkinson’s disease (PD) exhibit gait dysfunction, postural instability, and a propensity for falls. These dopamine (DA) replacement-resistant symptoms in part have been attributed to loss of basal forebrain (BF) cholinergi...

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Detalles Bibliográficos
Autores principales: Kucinski, Aaron, Sarter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969347/
https://www.ncbi.nlm.nih.gov/pubmed/33735392
http://dx.doi.org/10.1007/s00213-021-05822-x