NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA(H1047R) homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CA(H1047R) variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine hi...

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Detalles Bibliográficos
Autores principales: Madsen, Ralitsa R., Longden, James, Knox, Rachel G., Robin, Xavier, Völlmy, Franziska, Macleod, Kenneth G., Moniz, Larissa S., Carragher, Neil O., Linding, Rune, Vanhaesebroeck, Bart, Semple, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969366/
https://www.ncbi.nlm.nih.gov/pubmed/33514588
http://dx.doi.org/10.1242/dmm.048298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969366/
https://www.ncbi.nlm.nih.gov/pubmed/33514588
http://dx.doi.org/10.1242/dmm.048298

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