Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors

Pexidartinib is a kinase inhibitor that induces tumor response and improvements in symptoms and functional outcomes in adult patients with symptomatic tenosynovial giant cell tumor (TGCT). A population pharmacokinetic (PK) model for pexidartinib and its metabolite, ZAAD, was developed, and effects o...

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Detalles Bibliográficos
Autores principales: Yin, Ophelia, Wagner, Andrew J., Kang, Jia, Knebel, William, Zahir, Hamim, van de Sande, Michiel, Tap, William D., Gelderblom, Hans, Healey, John H., Shuster, Dale, Stacchiotti, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Pharmacometrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969430/
https://www.ncbi.nlm.nih.gov/pubmed/33043474
http://dx.doi.org/10.1002/jcph.1753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969430/
https://www.ncbi.nlm.nih.gov/pubmed/33043474
http://dx.doi.org/10.1002/jcph.1753

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