Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept

Background: Chronic low-grade inflammation and alterations in innate and adaptive immunity were reported in Type 2 diabetes (T2D). Here, we investigated the abundance and activation of T cells in the bone marrow (BM) of patients with T2D. We then verified the human data in a murine model and tested...

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Detalles Bibliográficos
Autores principales: Santopaolo, Marianna, Sullivan, Niall, Thomas, Anita Coral, Alvino, Valeria Vincenza, Nicholson, Lindsay B., Gu, Yue, Spinetti, Gaia, Kallikourdis, Marinos, Blom, Ashley, Madeddu, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969721/
https://www.ncbi.nlm.nih.gov/pubmed/33746953
http://dx.doi.org/10.3389/fimmu.2021.609406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969721/
https://www.ncbi.nlm.nih.gov/pubmed/33746953
http://dx.doi.org/10.3389/fimmu.2021.609406

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