Cargando…

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

B-cell acute lymphocytic leukemia (B-ALL), a common blood cancer in children, leads to high mortality. Cyclin-dependent kinase 9 inhibitor (CDK9i) effectively attenuates acute myeloid leukemia and chronic lymphoblastic leukemia by inducing apoptosis and inhibiting cell proliferation. However, the ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Wen-Li, Abudureheman, Tuersunayi, Xia, Jing, Chu, Lei, Zhou, Hang, Zheng, Wei-Wei, Zhou, Neng, Shi, Rong-Yi, Li, Ming-Hao, Zhu, Jian-Min, Qing, Kai, Ji, Chao, Liang, Kai-Wei, Guo, Sa, Yin, Gang, Duan, Cai-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969802/ https://www.ncbi.nlm.nih.gov/pubmed/33748130 http://dx.doi.org/10.3389/fcell.2021.641271

Ejemplares similares

CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism
por: Abudureheman, Tuersunayi, et al.
Publicado: (2021)

Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis
por: Zhang, Meng-Yi, et al.
Publicado: (2020)

The SIRT1-c-Myc axis in regulation of stem cells
por: Fan, Wei, et al.
Publicado: (2023)

BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer
por: Zhao, Ran, et al.
Publicado: (2021)

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway
por: Li, Chengjun, et al.
Publicado: (2022)

Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma
por: Guo, Yuanyuan, et al.
Publicado: (2021)

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE
por: Yang, Fan, et al.
Publicado: (2021)

Corrigendum: MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE
por: Yang, Fan, et al.
Publicado: (2021)

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
por: Dannappel, Marius Volker, et al.
Publicado: (2019)

The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II
por: Li, Jian, et al.
Publicado: (2021)

Molecular Crosstalk Between MYC and HIF in Cancer
por: Li, Yanping, et al.
Publicado: (2020)

IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway
por: Hong, Ting, et al.
Publicado: (2021)

CircCDYL Acts as a Tumor Suppressor in Wilms’ Tumor by Targeting miR-145-5p
por: Zhou, Rui, et al.
Publicado: (2021)

The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis
por: Schwarz, Jessica Denise, et al.
Publicado: (2022)

Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos
por: Sakai, Daisuke, et al.
Publicado: (2023)

Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway
por: Guo, Huijun, et al.
Publicado: (2022)

Development and Validation of a Prognostic Autophagy-Related Gene Pair Index Related to Tumor-Infiltrating Lymphocytes in Early-Stage Lung Adenocarcinoma
por: Wang, Zi-Hao, et al.
Publicado: (2021)

Strategies to Inhibit Myc and Their Clinical Applicability
por: Whitfield, Jonathan R., et al.
Publicado: (2017)

MYC and AMPK–Save Energy or Die!
por: Haikala, Heidi M., et al.
Publicado: (2017)

In vivo Reprogramming of Cancer Metabolism by MYC
por: Camarda, Roman, et al.
Publicado: (2017)

MYC function and regulation in physiological perspective
por: Jha, Rajiv Kumar, et al.
Publicado: (2023)

MYC—an emerging player in mitochondrial diseases
por: Purhonen, Janne, et al.
Publicado: (2023)

Erratum: The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis
por: Frontiers Production Office,
Publicado: (2022)

SNORA72 Activates the Notch1/c-Myc Pathway to Promote Stemness Transformation of Ovarian Cancer Cells
por: Zhang, Liwen, et al.
Publicado: (2020)

CDK4/6 inhibitor resistance in estrogen receptor positive breast cancer, a 2023 perspective
por: Zhou, Fiona H., et al.
Publicado: (2023)

Corrigendum: SNORA72 activates the Notch1/c-Myc pathway to promote stemness transformation of ovarian cancer cells
por: Zhang, Liwen, et al.
Publicado: (2022)

PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway
por: Li, Banban, et al.
Publicado: (2021)

GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis
por: Zhu, Han-Zhao, et al.
Publicado: (2021)

Chimeric Antigen Receptor T Cells Targeting Cell Surface GRP78 to Eradicate Acute Myeloid Leukemia
por: Yu, Wei, et al.
Publicado: (2022)

Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing
por: Gupta, Sanjeev Kumar, et al.
Publicado: (2020)

Functional Versatility of the CDK Inhibitor p57(Kip2)
por: Creff, Justine, et al.
Publicado: (2020)

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
por: Khattar, Ekta, et al.
Publicado: (2017)

Lessons in aging from Myc knockout mouse models
por: Prochownik, Edward V., et al.
Publicado: (2023)

Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis
por: Wang, Guishuan, et al.
Publicado: (2020)

IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
por: Guo, Xiaoyu, et al.
Publicado: (2021)

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium
por: Hishida, Tomoaki, et al.
Publicado: (2022)

The crosstalk between MYC and mTORC1 during osteoclastogenesis
por: Bae, Seyeon, et al.
Publicado: (2022)

Regulation of the somatotropic axis by MYC-mediated miRNA repression
por: Petrashen, Anna P., et al.
Publicado: (2023)

Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1
por: Chen, Bin, et al.
Publicado: (2020)

Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis
por: Liu, Ting-Ting, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h25mg2rhg16nvt6uims78mqvfk