The Discovery of Novel BCR-ABL Tyrosine Kinase Inhibitors Using a Pharmacophore Modeling and Virtual Screening Approach

Chronic myelogenous leukemia (CML) typically results from a reciprocal translocation between chromosomes 9 and 22 to produce the bcr-abl oncogene that when translated, yields the p210 BCR-ABL protein in more than 90% of all CML patients. This protein has constitutive tyrosine kinase activity that ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Ting-Ting, Wang, Xin, Qiang, Shao-Jia, Zhao, Zhen-Nan, Wu, Zhuo-Xun, Ashby, Charles R., Li, Jia-Zhong, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969810/
https://www.ncbi.nlm.nih.gov/pubmed/33748144
http://dx.doi.org/10.3389/fcell.2021.649434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969810/
https://www.ncbi.nlm.nih.gov/pubmed/33748144
http://dx.doi.org/10.3389/fcell.2021.649434

Ejemplares similares