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The Discovery of Novel BCR-ABL Tyrosine Kinase Inhibitors Using a Pharmacophore Modeling and Virtual Screening Approach

Chronic myelogenous leukemia (CML) typically results from a reciprocal translocation between chromosomes 9 and 22 to produce the bcr-abl oncogene that when translated, yields the p210 BCR-ABL protein in more than 90% of all CML patients. This protein has constitutive tyrosine kinase activity that ac...

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Detalles Bibliográficos
Autores principales:	Huang, Ting-Ting, Wang, Xin, Qiang, Shao-Jia, Zhao, Zhen-Nan, Wu, Zhuo-Xun, Ashby, Charles R., Li, Jia-Zhong, Chen, Zhe-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969810/ https://www.ncbi.nlm.nih.gov/pubmed/33748144 http://dx.doi.org/10.3389/fcell.2021.649434

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