Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice

GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of GPR37 in multiple models of infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia following challenge by lipopolysaccharide (LPS)...

Descripción completa

Detalles Bibliográficos
Autores principales: Bang, Sangsu, Donnelly, Christopher R., Luo, Xin, Toro-Moreno, Maria, Tao, Xueshu, Wang, Zilong, Chandra, Sharat, Bortsov, Andrey V., Derbyshire, Emily R., Ji, Ru-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969930/
https://www.ncbi.nlm.nih.gov/pubmed/33731716
http://dx.doi.org/10.1038/s41467-021-21940-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969930/
https://www.ncbi.nlm.nih.gov/pubmed/33731716
http://dx.doi.org/10.1038/s41467-021-21940-8

Ejemplares similares