Reduced spontaneous itch in mouse models of cholestasis

Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in cholestatic patients, but the pathophysiology is unclear. To study pruritus in mice, we measured scratch activity in cholestatic Atp8b1 mutant mice, a...

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Detalles Bibliográficos
Autores principales: Langedijk, Jacqueline, Bolier, Ruth, Tolenaars, Dagmar, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Waart, Dirk, Beuers, Ulrich, Bosma, Piter, Elferink, Ronald Oude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969945/
https://www.ncbi.nlm.nih.gov/pubmed/33731871
http://dx.doi.org/10.1038/s41598-021-85660-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969945/
https://www.ncbi.nlm.nih.gov/pubmed/33731871
http://dx.doi.org/10.1038/s41598-021-85660-1

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