Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We here show that USP39, a component of the spliceosome, is frequently overexpressed in high-grad...

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Detalles Bibliográficos
Autores principales: Wang, Shourong, Wang, Zixiang, Li, Jieyin, Qin, Junchao, Song, Jianping, Li, Yingwei, Zhao, Ling, Zhang, Xiyu, Guo, Haiyang, Shao, Changshun, Kong, Beihua, Liu, Zhaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969951/
https://www.ncbi.nlm.nih.gov/pubmed/33731694
http://dx.doi.org/10.1038/s41419-021-03581-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969951/
https://www.ncbi.nlm.nih.gov/pubmed/33731694
http://dx.doi.org/10.1038/s41419-021-03581-3

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