Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T. cruzi cytochrome CYP51, the target of azoles, does not deliver sterile c...

Descripción completa

Detalles Bibliográficos
Autores principales: Rocha-Hasler, Marianne, de Oliveira, Gabriel Melo, da Gama, Aline Nefertiti, Fiuza, Ludmila Ferreira de Almeida, Fesser, Anna Frieda, Cal, Monica, Rocchetti, Romina, Peres, Raiza Brandão, Guan, Xue Li, Kaiser, Marcel, Soeiro, Maria de Nazaré Correia, Mäser, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970121/
https://www.ncbi.nlm.nih.gov/pubmed/33747979
http://dx.doi.org/10.3389/fcimb.2021.617917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970121/
https://www.ncbi.nlm.nih.gov/pubmed/33747979
http://dx.doi.org/10.3389/fcimb.2021.617917

Ejemplares similares