Antiproliferative Activity of Some Newly Synthesized Substituted Pyridine Candidates Using 4-(Aaryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as Synthon

[Image: see text] Herein, we used nicotinonitrile derivatives 4a,b as scaffolds to build novel and active antineoplastic agents. The reaction of nicotinonitrile derivatives 4a,b with POCl(3)/PCl(5) and/or hydrazine hydrate afforded 2-chloropyridones 6a,b and 2-hydrazinyl nicotinonitrile derivatives...

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Detalles Bibliográficos
Autores principales: El-Sayed, Amira A., Elsayed, Elsayed A., Amr, Abd El-Galil E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970580/
https://www.ncbi.nlm.nih.gov/pubmed/33748628
http://dx.doi.org/10.1021/acsomega.1c00202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970580/
https://www.ncbi.nlm.nih.gov/pubmed/33748628
http://dx.doi.org/10.1021/acsomega.1c00202

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