A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs

Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new treatments for TB is hindered by the large number of candidate drugs, drug combinations, dosing choices, and complex pharmaco-kinetics/dynamics (PK/PD). Here we study the interplay of these factors in designing combin...

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Detalles Bibliográficos
Autores principales: Cicchese, Joseph M., Sambarey, Awanti, Kirschner, Denise, Linderman, Jennifer J., Chandrasekaran, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971003/
https://www.ncbi.nlm.nih.gov/pubmed/33707554
http://dx.doi.org/10.1038/s41598-021-84827-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971003/
https://www.ncbi.nlm.nih.gov/pubmed/33707554
http://dx.doi.org/10.1038/s41598-021-84827-0

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