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Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors
Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P(BAD)). The intrinsic limitation of P(BAD) for the gene expression i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971005/ https://www.ncbi.nlm.nih.gov/pubmed/33712706 http://dx.doi.org/10.1038/s41598-021-85372-6 |