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Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro

Traumatic brain injury (TBI) is associated with poor clinical outcomes; autopsy studies of TBI victims demonstrate significant oligodendrocyte progenitor cell (OPC) death post TBI; an observation, which may explain the lack of meaningful repair of injured axons. Whilst high-mobility group box-1 (HMG...

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Detalles Bibliográficos
Autores principales: Ved, R., Sharouf, F., Harari, B., Muzaffar, M., Manivannan, S., Ormonde, C., Gray, W. P., Zaben, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971069/
https://www.ncbi.nlm.nih.gov/pubmed/33731757
http://dx.doi.org/10.1038/s41598-021-84932-0