Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function

Human lung tumors exhibit robust and complex mitochondrial metabolism, likely precipitated by the highly oxygenated nature of pulmonary tissue. As ROS generation is a byproduct of this metabolism, reducing power in the form of nicotinamide adenine dinucleotide phosphate (NADPH) is required to mitiga...

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Detalles Bibliográficos
Autores principales: Ward, Nathan P., Kang, Yun Pyo, Falzone, Aimee, Boyle, Theresa A., DeNicola, Gina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971138/
https://www.ncbi.nlm.nih.gov/pubmed/32196080
http://dx.doi.org/10.1084/jem.20191689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971138/
https://www.ncbi.nlm.nih.gov/pubmed/32196080
http://dx.doi.org/10.1084/jem.20191689

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