An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy

Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several mechanisms of innate and acquired resistance to checkpoint blockade have been defined and include mutations of MHC I and IFNγ signaling pathwa...

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Detalles Bibliográficos
Autores principales: Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia V., Malley, Katie, Marquez, Eladio, Pollard, Jack, Qu, Hui, Roberts, Errin, Ryan, Sue, Singh, Kuldeep, Sun, Fangxian, Wang, Emma, Bahjat, Keith, Wiederschain, Dmitri, Wagenaar, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971263/
https://www.ncbi.nlm.nih.gov/pubmed/33796402
http://dx.doi.org/10.1080/2162402X.2021.1881268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971263/
https://www.ncbi.nlm.nih.gov/pubmed/33796402
http://dx.doi.org/10.1080/2162402X.2021.1881268

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