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An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several mechanisms of innate and acquired resistance to checkpoint blockade have been defined and include mutations of MHC I and IFNγ signaling pathwa...
Autores principales: | Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia V., Malley, Katie, Marquez, Eladio, Pollard, Jack, Qu, Hui, Roberts, Errin, Ryan, Sue, Singh, Kuldeep, Sun, Fangxian, Wang, Emma, Bahjat, Keith, Wiederschain, Dmitri, Wagenaar, Timothy R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971263/ https://www.ncbi.nlm.nih.gov/pubmed/33796402 http://dx.doi.org/10.1080/2162402X.2021.1881268 |
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