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Hedgehog Pathway Inhibitors: Clinical Implications and Resistance in the Treatment of Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer and is on the rise. Most BCCs are benign; however, a very small percentage are locally advanced and metastatic. The pathway that normally regulates cell growth and proliferation is directed by the hedgehog pathway (HP). In BCC, i...

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Detalles Bibliográficos
Autores principales: Habashy, Suzanne, Jafri, Aliya, Osman, Hiba O, Thomas, Neena E, Udekwe, Somtochi, Heindl, Stacey E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971714/
https://www.ncbi.nlm.nih.gov/pubmed/33754119
http://dx.doi.org/10.7759/cureus.13859