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Protein sequence optimization with a pairwise decomposable penalty for buried unsatisfied hydrogen bonds
In aqueous solution, polar groups make hydrogen bonds with water, and hence burial of such groups in the interior of a protein is unfavorable unless the loss of hydrogen bonds with water is compensated by formation of new ones with other protein groups. For this reason, buried “unsatisfied” polar gr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971855/ https://www.ncbi.nlm.nih.gov/pubmed/33684097 http://dx.doi.org/10.1371/journal.pcbi.1008061 |