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The evolutionary origin of the universal distribution of mutation fitness effect

An intriguing fact long defying explanation is the observation of a universal exponential distribution of beneficial mutations in fitness effect for different microorganisms. To explain this effect, we use a population model including mutation, directional selection, linkage, and genetic drift. The...

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Detalles Bibliográficos
Autores principales: Barlukova, Ayuna, Rouzine, Igor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971868/
https://www.ncbi.nlm.nih.gov/pubmed/33684109
http://dx.doi.org/10.1371/journal.pcbi.1008822