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A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development

During early mammalian embryo development, a small number of cells make robust fate decisions at particular spatial locations in a tight time window to form inner cell mass (ICM), and later epiblast (Epi) and primitive endoderm (PE). While recent single-cell transcriptomics data allows scrutinizatio...

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Detalles Bibliográficos
Autores principales: Cang, Zixuan, Wang, Yangyang, Wang, Qixuan, Cho, Ken W. Y., Holmes, William, Nie, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971879/
https://www.ncbi.nlm.nih.gov/pubmed/33684098
http://dx.doi.org/10.1371/journal.pcbi.1008571