Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level

We investigated germline variation in pancreatic ductal adenocarcinoma (PDAC) predisposition genes in 535 patients, using a custom-built panel and a new complementary bioinformatic approach. Our panel assessed genes belonging to DNA repair, cell cycle checkpoints, migration, and preneoplastic pancre...

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Detalles Bibliográficos
Autores principales: Zimmermann, Michael T., Mathison, Angela J., Stodola, Tim, Evans, Douglas B., Abrudan, Jenica L., Demos, Wendy, Tschannen, Michael, Aldakkak, Mohammed, Geurts, Jennifer, Lomberk, Gwen, Tsai, Susan, Urrutia, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973372/
https://www.ncbi.nlm.nih.gov/pubmed/33747920
http://dx.doi.org/10.3389/fonc.2021.606820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973372/
https://www.ncbi.nlm.nih.gov/pubmed/33747920
http://dx.doi.org/10.3389/fonc.2021.606820

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