Cargando…
Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level
We investigated germline variation in pancreatic ductal adenocarcinoma (PDAC) predisposition genes in 535 patients, using a custom-built panel and a new complementary bioinformatic approach. Our panel assessed genes belonging to DNA repair, cell cycle checkpoints, migration, and preneoplastic pancre...
Autores principales: | Zimmermann, Michael T., Mathison, Angela J., Stodola, Tim, Evans, Douglas B., Abrudan, Jenica L., Demos, Wendy, Tschannen, Michael, Aldakkak, Mohammed, Geurts, Jennifer, Lomberk, Gwen, Tsai, Susan, Urrutia, Raul |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973372/ https://www.ncbi.nlm.nih.gov/pubmed/33747920 http://dx.doi.org/10.3389/fonc.2021.606820 |
Ejemplares similares
-
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers
por: Chi, Young-In, et al.
Publicado: (2022) -
Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks
por: Urrutia, Guillermo, et al.
Publicado: (2021) -
Single and combinatorial chromatin coupling events underlies the function of transcript factor krüppel-like factor 11 in the regulation of gene networks
por: Calvo, Ezequiel, et al.
Publicado: (2014) -
Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022) -
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1
por: Chi, Young-In, et al.
Publicado: (2023)