Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among these systems for the novel tumor-targeted antifolates AGF94 (t...

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Detalles Bibliográficos
Autores principales: O’Connor, Carrie, Wallace-Povirk, Adrianne, Ning, Changwen, Frühauf, Josephine, Tong, Nian, Gangjee, Aleem, Matherly, Larry H., Hou, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973545/
https://www.ncbi.nlm.nih.gov/pubmed/33737637
http://dx.doi.org/10.1038/s41598-021-85818-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973545/
https://www.ncbi.nlm.nih.gov/pubmed/33737637
http://dx.doi.org/10.1038/s41598-021-85818-x

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