Population pharmacokinetic model development and its relationship with adverse events of oxcarbazepine in adult patients with epilepsy

This study aimed to develop a pharmacokinetic (PK) model of oxcarbazepine (OXC) and analyse the relationship between monohydroxylated derivative (MHD), an active metabolite of OXC, and the adverse events of OXC. We obtained 711 OXC samples from 618 patients with epilepsy who were enrolled in the Epi...

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Detalles Bibliográficos
Autores principales: Jang, Yoonhyuk, Yoon, Seonghae, Kim, Tae-Joon, Lee, SeungHwan, Yu, Kyung-Sang, Jang, In-Jin, Chu, Kon, Lee, Sang Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973549/
https://www.ncbi.nlm.nih.gov/pubmed/33737678
http://dx.doi.org/10.1038/s41598-021-85920-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973549/
https://www.ncbi.nlm.nih.gov/pubmed/33737678
http://dx.doi.org/10.1038/s41598-021-85920-0

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