Cargando…
Population pharmacokinetic model development and its relationship with adverse events of oxcarbazepine in adult patients with epilepsy
This study aimed to develop a pharmacokinetic (PK) model of oxcarbazepine (OXC) and analyse the relationship between monohydroxylated derivative (MHD), an active metabolite of OXC, and the adverse events of OXC. We obtained 711 OXC samples from 618 patients with epilepsy who were enrolled in the Epi...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973549/ https://www.ncbi.nlm.nih.gov/pubmed/33737678 http://dx.doi.org/10.1038/s41598-021-85920-0 |