Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model

Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cytokine Signaling-1 (SOCS1) is an inducible, intracellular prot...

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Detalles Bibliográficos
Autores principales: Sharma, Jatin, Collins, Teresa D., Roach, Tracoyia, Mishra, Shiwangi, Lam, Brandon K., Mohamed, Zaynab Sidi, Veal, Antia E., Polk, Timothy B., Jones, Amari, Cornaby, Caleb, Haider, Mohammed I., Zeumer-Spataro, Leilani, Johnson, Howard M., Morel, Laurence M., Larkin, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973732/
https://www.ncbi.nlm.nih.gov/pubmed/33737712
http://dx.doi.org/10.1038/s41598-021-86017-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973732/
https://www.ncbi.nlm.nih.gov/pubmed/33737712
http://dx.doi.org/10.1038/s41598-021-86017-4

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